During this presentation followed by Q&A discussion, Dr. Barnett will describe various psychedelic compounds, their known mechanisms of action, and various subjective effects. He will review the past and current literature on the potential therapeutic benefits, as well as the risks, of psychedelic medicines on a variety of clinical conditions. Finally, he will discuss “trends and issues” in the broader psychedelic medicine field with a look at future directions. Discussion may also include psychedelic experiences outside of Western medical and research models, such as personal use, indigenous traditions, and religious use.